Gs-coupled protein receptor
The Gs-(stimulatory) protein specifically stimulates the enzyme adenylate cyclase that is attached to the cell membrane. Adenylate cyclase activity is activated when it binds to a subunit of the activated G protein. This enzyme converts ATP (adenosine triphosphate) into cyclic AMP (cAMP= cyclic adenosine monophosphate). Activation of adenylate cyclase ends when the G protein returns to the GDP-bound state.
cAMP is an important second messenger and is involved in cellular functions such as metabolism, cell division and differentiation. cAMP can initiate these functions by activating protein kinase A (PKA).
The following receptors are examples of GPCRs coupling to the Gs subunit. In the TRC, the Gs coupled receptor is always represented as green receptor: