Paroxysmal depolarising shift

Cellular dysregulation Paroxysmal depolarising shift (PDS)

Seizures are initiated by abnormal depolarisations in a neuron or group of neurons. The paroxysmal depolarising shift is a sudden abnormal depolarisation which is characterized by a train of action potentials.

So in contrast to the normal physiological situation in which the sodium channel is inactivated during the repolarisation, now the channels are still activated generating a number of depolarisations.


Which of the following is NOT commonly associated with neuronal membrane instability? 


For an action potential to begin, an area of excitable membrane must


During the absolute refractory period, the membrane