Treatment of female hypogonadism (f)
Treatment of female hypogonadism
The problem of hypogonadism and female infertility can be treated at all three levels of the hypothalamic-pituitary-testis axis depending on the localization of the disorder. The following hormone supplements are used:
- GnRH agonists such as gonadorelin mimic the action of GnRH when administered in a pulsatile manner. These agents are used to treat hypogonadism with hypothalamic dysfunction.
- Gonadotropins are used to treat secondary hypogonadism. Ovarian stimulation is achieved with follitropin (recombinant FSH) or hMG (menopause gonadotropin).HMG is prepared from urine of postmenopausal women and is a much cheaper option than recombinant FSH.Induction of ovulation is stimulated with lutropin (LH) or human chorionic gonadotropin (hCG). The structure of hCG is very similar to the structure of LH.
- Estrogens in the micronised form are used in cases of primary hypogonadism and hypopituitarism. The micronised form is better water-soluble and thus better absorbed than the pure form (which is highly lipophilic).
A female with Turner’s syndrome (gonadal dysgenesis) requires:
Extra info: Since the gonads have not developed, they don’t produce their hormones. Replacement therapy with estrogens stimulates the development of breasts and uterus and prevents osteoporosis. Progesterone added to this therapy prevents spotting.