Opiate receptors in GI

Opiate receptors

The opioid μ-receptor is present on the myenteric neurons. When agonists are present, the activated μ-receptor will inhibit acetylcholine release from the neuron, resulting in decreased GI motility. This effect occurs at dosages lower than that required for analgesia.

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The main mechanism of opiates in treating diarrhoea is: