TRC: Alpha-receptor agonists in urology

α-adrenergic receptor agonists

α-sympathicomimetics or α-adrenergic receptor agonists such as phenylpropanolamine and ephedrine increase intraurethral pressure. The α-adrenergic receptors in bladder and proximal urethra are stimulated.

This stimulation will evoke an increased tone of the sphincter mechanism and thus improve closure of the bladder.

I α-adrenergic receptor agonists used in the treatment of incontinence do NOT have systemic adverse effects.

II ephedrine may be effective when used prophylactically in certain stress situations.

Extra info: α1-adrenergic receptors are found throughout the body and as such these drugs can cause mydriasis, tremulousness, anxiety, and elevated blood pressure.

Option explanation:

I is true, II is true

I is true, II is false

I is false, II is true

I is false, II is false

α-adrenergic receptor agonists

α-adrenergic receptor agonists

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