H2-antagonists were originally introduced for the treatment of peptic ulcers (see H2-antagonists for ulcers). However, due to the high relapse rate of reflux patients taking antacids, maintenance therapy with H2-receptor antagonists (or PPI's) is often indicated.
Tolerance can occur and patients chronically using the H2-antagonists may require higher dosages than normal.
Famotidine and ranitidine act as anti-ulcer drugs because of antagonism at the parietal cell of
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