In cancer cells, the growth is out of control. It begins with a mutation in a portion of DNA, which leads to the production of abnormal proteins. A mutation in genes involved in cell growth (proto-oncogenes), differentiation or mitosis, can result in uncontrolled growth. The proto-oncogene becomes an oncogene (1). These abnormal proteins can behave as growth stimulating factor or cell division promoting protein. So, more growth stimulating factors are
What is NOT true?
Extra info: Close Proto-oncogenes regulate normal cell division. When these genes are mutated, they can disregulate cell division.
Compared with benign tumours, neoplastic tumours do NOT show:
Extra info: Uniform cell mass is a feature of benign tumour
What is true about a tumor suppressor gene?
Extra info: Tumor suppressor genes appear in all cells, are not controlled by oncogenes and certainly do not code for proteins which stimulate cell division.