Vasopressin

Vasopressin

Synthetic vasopressin or desmopressin has a stronger and more prolonged action in comparison with natural

vasopressin. Vasopressin binds to the V2 receptor in tubular cells. This leads to in increase in intracellular cAMP, which activates specific membrane proteins. As a result, the membrane becomes more permeable to water and so water can be reabsorbed. Diabetes insipidus is the most important indication for vasopressin therapy.
Intranasal administration, intravenous administration or oral administrations are possible routes of administration in diabetes insipidus.

1

Overdosage over desmopressin (=vasopressin/ADH) does NOT exist.