Distribution in elderly
Changes in drug distribution are theoretically due to alterations in body composition and serum protein binding. Regarding body composition, elderly do have decreased lean body mass and decreased total body water. The contribution of fat tissue to the total body composition is increased. The clinical importance is a reduction of the half-lives of water-soluble drugs (digoxin, ethanol, ciprofloxacin, antipyrine, and cimetidine), since their distribution volume is reduced. Conversely, lipophilic drugs (benzodiazepines, tolbutamide) exhibit an increase in distribution volume and half-life.
Distribution to peripheral tissues is poor due to:
Would an elderly patient with an intramuscular shot of a lipophilic drug have a shorter or longer duration of action compared to a younger patient?
Extra info: A lipophilic drug will have a longer duration of action, because its volume of distribution is larger in elderly people (who have more fat tissue).