Parasympatholytics

Parasympatholytics

Parasympatholytics or spasmolytics (oxybutynin, tolterodine, and solifenacin) increase bladder capacity by inhibition of detrusor contractions. In fact these drugs are antagonists for the postsynaptic muscarinic receptors and thus prevent acetylcholine from binding to its receptor.

In this way, the parasympatholytics decrease the parasympathetic influence on the detrusor. Moreover, these drugs are also able to extend the time of urgency to urinate.