High potency antipsychotics
Haloperidol’s receptor affinity can best be described as D1, D2 > α1> 5-HT2A, M1.
Extra info: aloperidol's activity can best be described as D2 > α1> 5-HT2A, M1, haloperidol does not significant D1 activity.
High potency antipsychotics are the principle etiology of acute dystonias.
Extra info: High potency antipsychotics are the most common cause as they lack a counter balance of antagonism of the muscarinic receptor.
The 5-HT2A-antagonism activity of haloperidol is insufficient to overcome the D2 antagonism.
Extra info: Haloperidol's activity of 5HT2A antagonism is much too low to counterbalance its D2 antagonism.