TRC: Mineralocorticoids

Mineralocorticoids

Mineralocorticoids play an important role in water and salt balance control. They stimulate retention of sodium ions against the loss of potassium ions in urine. Mineralocorticoids bind to a mineralocorticoid-receptor in the nucleus. This complex can interact with a specific binding site on the DNA, resulting in transcription of genes.

Fludrocortisone is the only mineralocorticoid with clinical application. In Addison's the dose of fludrocortisone is between 0.05-0.2 mg daily in combination with 20 mg hydrocortisone.

I. Fludrocortisone exerts its action in the proximal tubule in the kidney.

II. Mineralocorticoid deficiency can cause hypernatremia.

Extra info: Fludrocortisone acts on the distal tubule in the kidney. Aldosterone deficiency results in a decreased resorption of sodium ions and thus hyponatremia.

Option explanation:

I is true, II is false

I is true, II is true

I is false, II is false

I is false, II is true

Mineralocorticoids

Mineralocorticoids

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