Mineralocorticoids play an important role in water and salt balance control. They stimulate retention of sodium ions against the loss of potassium ions in urine. Mineralocorticoids bind to a mineralocorticoid-receptor in the nucleus. This complex can interact with a specific binding site on the DNA, resulting in transcription of genes.
I. Fludrocortisone exerts its action in the proximal tubule in the kidney.
II. Mineralocorticoid deficiency can cause hypernatremia.
Extra info: Fludrocortisone acts on the distal tubule in the kidney. Aldosterone deficiency results in a decreased resorption of sodium ions and thus hyponatremia.