Spironolactone is a specific antagonist of the mineralocorticoid receptor in the distal tubules of the kidney. Spironolactone counteracts the actions of aldosterone and thus has a natriuretic and potassium-sparing effect. It is the drug of choice in the treatment of hyperaldosteronism (100-150 mg divided over different doses daily).


For more information on spironolactone in another context, see the chapters of cardiology and renal diseases.


I. Spironolactone can be used to treat hypertension due to pheochromocytoma.

II. Hypokalemia is a contraindication for the use of spironolactone.