Spironolactone is a specific antagonist of the mineralocorticoid receptor in the distal tubules of the kidney. Spironolactone counteracts the actions
I. Spironolactone can be used to treat hypertension due to pheochromocytoma. II. Hypokalemia is a contraindication for the use of spironolactone.
Extra info: For the preoperative treatment of pheochromocytoma alpha and beta-blocking agents are required. Spironolactone has a potassium-sparing effect and will (partly) cure the hypokalemia. Hyperkalemia is a contraindication.