TRC: Treatment of hyperlipidemia

Treatment of hyperlipidemia

Non-pharmacological treatment of hyperlipidemia mainly aims at decreasing cardiovascular risk factors: losing weight, stop smoking, and increasing exercise. A diet consisting of low

saturated fat intake, fish, fruit, vegetables and fibers might decrease cholesterol levels up to 10%. If these factors are not sufficient in decreasing LDL levels, pharmacological treatment is required. Drug treatment includes a variety of agents (statins, bile acid resins, fibric acid derivatives, nicotinic acid, fish oils, and ezetimibe) that affect cholesterol synthesis, cholesterol losses in bile and LDL and VLDL metabolism.

Which of the following is false?

Extra info: Answers a, b, and d are true

for every 1% decrease in LDL, the risk of coronary heart disease is reduced by 1%

both low HDL and high triglyceride levels have been shown to independently predict coronary heart disease risk

each 1% increase in LDL has been associated with a 7% to 8% increase in coronary heart disease events

HDL has been correlated with coronary heart disease events regardless of total cholesterol or LDL levels.

What are some indications and advantages of combination therapy?

it can act at different stages of lipid metabolism

it is an important option for patients who have persistent abnormalities of more than one component of the lipid profile

it provides an option for patients who have not achieved lipid goals after monotherapy

all of the above

Treatment of hyperlipidemia

Treatment of hyperlipidemia

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