CYP P450 induction
Some drugs are able to increase the activity of the microsomal enzymes and thus increase the clearing ability of the liver. These are called inducers. As shown in the graphic, when an inducing drug is added to steady-state concentrations of a drug which is a substrate, this leads to a reversible increase in enzyme activity resulting in a decrease in the substrates serum concentrations.
The effects of enzyme induction can been typically be seen after the first 2 days, but maximal effects may take more a week.
Look at the clinical example shown in the
See how an inducer effects the concentration of another drug by clicking here and selecting "add inducer".